Physical activity and multiple sclerosis: new insights regarding inactivity

Multiple sclerosis: new insights and trends.

The past few years have witnessed major advancements in our ability to diagnose multiple sclerosis (MS) and begin treatments that can favorably modify the course of the disease. In addition, there is now a much better understanding of the pathogenesis of the disease and an increasing interest in “decoding” the complex genetic factors responsible for, not only the susceptibility to the disease, ...

Multiple Sclerosis, Physical Therapy, and Quality of Life Insights

Physical Activity, Inactivity, and Health During Youth.

2016 has been an exciting year for research in physical activity, inactivity and health. Recognition of the importance of all physical behaviours (physical activity, sedentary time and sleep) across the 24 h day continues to grow. Notable advances have included: applications of recent methodological innovations that account for the co-dependence of the behaviours in the finite 24 h period showi...

Epidemiology and natural history of multiple sclerosis: new insights.

PURPOSE OF REVIEW The cause of multiple sclerosis remains elusive. We review recent epidemiological studies of genetic and environmental factors that influence susceptibility to the disease and its clinical course. RECENT FINDINGS Genetic advances strengthen the association of multiple sclerosis with the human leukocyte antigen (HLA)-DRB1 allele and interferon-gamma polymorphisms and suggest ...

Multiple sclerosis--novel insights and new therapeutic strategies.

PURPOSE OF REVIEW This review focuses on novel aspects of the pathogenesis and advances in the therapy of multiple sclerosis (MS). RECENT FINDINGS Recent observations suggest that early lesion development in MS may start in some forms with oligodendrocyte death and that inflammation appears as a secondary phenomenon only. The lack of sufficient remyelination in MS may be the result of a distu...